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Publication history In 1946, the book was published by Knopf. Film adaptations In 1949, the story was made into a film of the same name directed by Richard Wallace and starring Gordon MacRae and Margaret Lindsay. In 1985, the story was filmed again as an independent film of the same name directed by Alain Corneau and starring Michelle Pfeiffer and Steve Guttenberg. References External links Category:1946 American novels Category:Novels by William Saroyan Category:American novels adapted into films Category:Random House books Category:Novels set in Turkey Category:American novels adapted into playsEfficacy of Probiotics in the Treatment of Inflammatory Bowel Disease. Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract. It is manifested as ulcerative colitis or Crohn's disease, and is associated with increased intestinal permeability, dysregulated immune responses, abnormal bacterial colonization, and subsequent oxidative stress and mucosal damage. The etiology of IBD is not yet fully understood. Genetic predisposition, immune dysregulation, bacterial dysbiosis, and environmental factors are all potentially involved. Although, the response to medical therapy varies in patients with IBD, the addition of certain probiotics and prebiotics to the treatment of IBD has been shown to be beneficial. The purpose of this review is to evaluate the efficacy of probiotics and prebiotics in the treatment of IBD. We performed a literature search using the MEDLINE, EMBASE, and Cochrane databases to identify clinical studies that have examined the effects of probiotics or prebiotics in the treatment of IBD. Out of the 11 studies reviewed, 4 studies examined the efficacy of probiotics in the treatment of IBD and 7 studies evaluated the effect of prebiotics in patients with IBD. Of these 11 studies, 3 studies examined the efficacy of probiotics in Crohn's disease and 2 studies examined the efficacy of probiotics in ulcerative colitis. Several studies examined the effects of both probiotics and prebiotics, and found that the probiotics administered, as well as the source of probiotics, had an effect on the clinical outcomes measured. Although, there is currently limited evidence for the use of probiotics in the treatment of IBD, it appears that the use of certain probiotics may improve the clinical outcomes measured.Q: How to



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